Synthesis of a Complex of Ferulic Acid Incorporation into the Cavity of Modified Β-Cyclodextrin

Keywords

β-cyclodextrin, surface modification, encapsulation

Abstract

This study aimed to synthesize and characterize inclusion complexes of ferulic acid incorporation based on modified β-cyclodextrin (MCD). Ferulic acid (FA), a natural antioxidant with limited water solubility, is challenging to deliver effectively to the human body. Therefore, to konoenhance its stability and solubility, it was encapsulated in cyclodextrin with a modified surface. The interaction between ferulic acid and the modified β-cyclodextrin compound was confirmed through Fourier transform infrared spectrometry (FT-IR). The thermogravimetric analysis (TGA) indicated that the successful encapsulation of ferulic acid in the β-cyclodextrin cavity led to increased thermal stability of the FA-MCD inclusion complex compared to the individual components. These findings suggest that the modified β-cyclodextrin can serve as a promising carrier for improving the delivery and effectiveness of ferulic acid as an antioxidant in various pharmaceutical applications.

References

1. Glotov A., Stavitskaya A., Novikov A., Semenov A., Ivanov E., Gushchin P. and Lvov Y. Halloysite Based Core-Shell Nanosystems: Synthesis and Application // Nanomaterials from Clay Minerals – 2019. – P. 203-256. https://doi.org/10.1016/B978-0-12-814533-3.00004-1
2. Řezanka M. Synthesis of cyclodextrin derivatives // Cyclodextrin Fundamentals, Reactivity and Analysis – 2018. – P. 57-103. https://doi.org/10.1007/978-3-319-76159-6_2
3. Mura P. Analytical techniques for characterization of cyclodextrin complexes in aqueous solution: A review. // Pharm. Biomed. Anal. – 2014. – 101. – P. 238-250. https://doi.org/10.1016/j.jpba.2014.02.022
4. Di Cagno M., Stein P. C., Skalko-Basnet N., Brandl M. and Bauer-Brandl A. Solubilization of ibuprofen with β-cyclodextrin derivatives: Energetic and structural studies. // Pharm. Biomed. Anal. – 2011. – 55. – P. 446-451. https://doi.org/10.1016/j.jpba.2011.02.022
5. Abarca R.L., Rodríguez F.J., Guarda A., Galotto M. J. and Bruna J.E. Characterization of beta-cyclodextrin inclusion complexes containing an essential oil component. // Food Chem. – 2016. – 196. – P. 968-975. https://doi.org/10.1016/j.foodchem.2015.10.023
6. Zhao D.H., Ke C.L., Liu Q., Wang X.F., Wang Q. and Li L.D. Elimination kinetics of eugenol in grass carp in a simulated transportation setting // BMC veterinary research – 2017. – 13 – No. 346.
   https://doi.org/10.1186/s12917-017-1273-3